منابع مشابه
From Individuals to Groups and Back: The Evolutionary Implications of Group Phenotypic Composition
There is increasing interest in understanding the processes that maintain phenotypic variation in groups, populations, or communities. Recent studies have investigated how the phenotypic composition of groups or aggregations (e.g., its average phenotype or phenotypic variance) affects ecological and social processes, and how multi-level selection can drive phenotypic covariance among interactin...
متن کاملPhenotypic heterogeneity in modeling cancer evolution
The unwelcome evolution of malignancy during cancer progression emerges through a selection process in a complex heterogeneous population structure. In the present work, we investigate evolutionary dynamics in a phenotypically heterogeneous population of stem cells (SCs) and their associated progenitors. The fate of a malignant mutation is determined not only by overall stem cell and non-stem c...
متن کاملEditorial: Cellular and Phenotypic Plasticity in Cancer
1 Oncogenic Signalling and Growth Control Program and Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia, 2 The Sir Peter MacCallum Department of Oncology, The University of Melbourne, East Melbourne, VIC, Australia, 3 Cancer Immunobiology, Olivia Newton-John Cancer Research Institute, Heidelberg, VIC, Australia, 4 School of Cancer Medicine, La Trobe Univ...
متن کاملComposition and applications of focus libraries to phenotypic assays
The wealth of bioactivity information now available on low-molecular weight compounds has enabled a paradigm shift in chemical biology and early phase drug discovery efforts. Traditionally chemical libraries have been most commonly employed in screening approaches where a bioassay is used to characterize a chemical library in a random search for active samples. However, robust curating of bioas...
متن کاملPhenotypic characteristics of chemical composition of m. longissimus dorsi in Croatian Simmental bulls phenotypic characteristics oF CHEmiCal ComPosition oF m. lonGissimus dorsi in Croatian simmEntal bulls
Simmental breed is known as a dual purpose breed widely spread in the Republic of Croatia. It represents more than two thirds of overall cattle population in Croatia. In this experiment we have focused on chemical components (dry matter, water, protein, fat and ash) in musculus longissimus dorsi (MLD) and its phenotypic characteristics. The trial comprised 710 young bulls, the progeny of sires ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: eLife
سال: 2021
ISSN: 2050-084X
DOI: 10.7554/elife.63518